Metaanalysis of chronic pallidal stimulation in children with DYT-1 dystonia
Neuropediatrics(2008)
Abstract
Introduction: DYT1-dystonia is an autosomal-dominant disease with a penetrance rate of 30–40% and usually starts in childhood between the age 8–12 severely disabling some patients over time. Medical therapy with anti-cholinergic drugs or dopamine is often ineffective and may produce severe side effects. Recent reports suggest that chronic bilateral pallidal stimulation leads to major improvement in these patients.
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Key words
Deep Brain Stimulation
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