Discovery Of Micromolar Pde-Iv Inhibitors That Exhibit Much Reduced Affinity For The [H-3]Rolipram Binding-Site - 3-Norsornyloxy-4-Methoxyphenylmethylene Oxindoles

The synthesis and the in vitro properties of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described. Despite bearing structural similarity to rolipram, several of these compounds have much reduced affinity for the [H-3]rolipram binding site.