Combination of Grading and New Biological Factors (S-Phase Fraction and Epidermal Growth Factor Receptor) Can Predict Relapse and Survival in Patients with Node-Negative Primary Breast Cancer

Background: In most cases of node-negative breast cancer, clinical outcome is relatively good after surgical treatment. It is necessary, however, to determine prognostic factors for the identification of high- and low-risk subgroups concerning recurrence and death, because only patients with excellent prognosis require no further treatment. The objective of the study was to select a few potential factors for a prognostic index that can be used in clinical practice.