2-Aminoimidazoles inhibitors of TGF-β receptor 1

Dominique Bonafoux,Claudio Chuaqui,P. Ann Boriack-Sjodin,Chris Fitch,Gretchen Hankins,Serene Josiah,Cheryl Black,Gregg Hetu,Leona Ling,Wen-Cherng Lee

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

Acylated 2-amidoimidazoles were identified as potent and selective inhibitor of TGF-βR1 that offer a superior pharmacokinetic profile compared to unsubstituted or alkylated 2-aminoimidazoles.

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关键词

2-Amidoimidazoles,TGF-βR1,X-ray structure,PK

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