Pancreaticoduodenectomy for advanced gastric cancer
Gastric Cancer(2005)
Abstract
Background Although pancreaticoduodenectomy has been rarely performed for gastric caner because of frequent morbidity and mortality, some favorable results after this procedure have been reported recently. Our objective was to present our data that might aid in the selection of patients to undergo this procedure. Methods Between 1970 and 2001, 23 patients who had pancreaticoduodenectomy for gastric cancer with tumor invading the pancreatic head were identified, and they were the subjects of this study. Clinical, operative, and pathological data, and morbidity and mortality rates were collected and analyzed. Survival outcome was also calculated and analyzed. Results Five patients underwent this procedure for disease in the gastric remnant, 18 undergoing the procedure for primary tumors. Median operating time was 8 h (range, 6–13 h), and median blood loss was 1600 ml (range, 700–16 000 ml). Regarding extent of gastrectomy, all patients with primary cancer ( n = 18) underwent a distal gastrectomy and patients with disease in the gastric remnant ( n = 5) underwent a completion gastrectomy. Incurable factors, including paraaortic lymph node metastasis, positive lavage cytology, or peritoneal dissemination were found in 8 patients. The postoperative morbidity rate was 73.9%; however, operation-related death was zero. The overall 5-year survival rate was 34.3%. The 5-year survival rate of the 8 patients with incurable factors was 0%, while that of the 15 patients without incurable factors was 47.4%. Conclusion If an R0 resection can be achieved by pancreaticoduodenectomy, this procedure should be performed for patients with tumor invading the pancreatic head. Patients with incurable factors should not be considered for pancreaticoduodenectomy.
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Key words
Gastric cancer,Pancreaticoduodenectomy,Combined resection of adjacent organs
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