Pyrazinoindolone inhibitors of MAPKAP-K2

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Optimization of pyrazinoindolone inhibitors of MAPKAP-K2 (MK2) provides a reasonable balance of cellular potency and physicochemical properties. Mechanistic studies support the inhibition of MK2 which is responsible for the sub-micromolar cellular efficacy.

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关键词

MAPKAP-K2,THP-1

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