Porcine Cytomegalic Inclusion Disease Virus - Electron Microscopic Study Of Nasal Mucosa

Summary An electron microscopic study was made on porcine cytomegalic inclusion disease virus in the nasal mucosa of three piglets from a herd with a history of generalized cytomegalic inclusion disease. In addition to previously described viral developmental forms within the nucleus and enveloped virus particles between the nuclear membranes, the study revealed enveloped virus particles within membrane-enclosed clusters in the nucleus, and reduplication of nuclear membranes. In the cytoplasm, enveloped virus particles, 120–150 m? in diameter, were found within vacuoles. Unenveloped virus particles, 90–110 m? in diameter, were located free in the cytoplasm and often showed a crystal pattern.