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白血病患者染色体核型分析及其在临床诊断中的应用

JOURNAL OF JINING MEDICAL UNIVERSITY(2010)

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Abstract
目的 探讨白血病患者的细胞遗传学特点及其临床意义.方法 259例白血病患者,采用骨髓细胞24h培养法制备染色体,R显带后镜检分析其核型.结果 259例患者中异常核型187例,异常率72.20%.其中AML、ALL、CML、CLL患者异常率分别为58.82%,45.95%,97.32%,22.22%.AML中M2,M3,M4,M5的异常率分别为66.67%,90.91%,12.50%,20.0%.结论 染色体核型分析对白血病的辅助诊断具有重要意义.
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