Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV.

Takashi Kondo,Isamu Sugimoto,Takahiro Nekado,Kenya Ochi,Tazumi Ohtani,Yohei Tajima,Susumu Yamamoto,Kazuhito Kawabata,Hisao Nakai,Masaaki Toda

Bioorganic & Medicinal Chemistry（2007）

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摘要

The 4β-[4-(hydroxyphenyl)prolyl]prolinenitriles were synthesized and evaluated as inhibitors of dipeptidylpeptidase IV (DPP-IV). Metabolic formation of the corresponding phenol glucuronates was found to contribute to their long duration of action.

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关键词

DPP-IV inhibitor,Prolylprolinenitriles,Glucuronate

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