羟苯磺酸钙联合甲钴胺治疗糖尿病周围神经病变的疗效观察
Drugs & Clinic(2011)
Abstract
目的评价羟苯磺酸钙联合甲钴胺治疗糖尿病周围神经病变(DPN)的疗效。方法将60例DPN患者随机分为羟苯磺酸钙联合甲钴胺治疗组(n=30)和甲钴胺对照组(n=30),联合治疗组口服羟苯磺酸钙胶囊0.5g、甲钴胺片0.5mg;对照组口服甲钴胺片0.5mg;均每日3次,疗程12周。观察治疗前后患者的腓神经传导速度、神经系统症状及体征变化。结果治疗组总有效率为93.3%,对照组为63.3%,治疗组在改善运动神经与感觉神经的传导速度、神经系统症状评分及体征评分方面均优于对照组(P<0.05)。结论羟苯磺酸钙联合甲钴胺治疗DPN疗效优于甲钴胺单一治疗。
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Key words
diabetic peripheral neuropathy(DPN),calcium dobesilate,effective observation,nervusperoneus,mecobalamin
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