Novel Polymer Vectors of 64Cu

We describe a preparation of novel polymer vectors of Cu-64 based on co-polymers of poly-(N-isopropylacrylamide) and poly-(N-hydroxypropylmethacrylamide). DOTA, DTPA, dipicolylamine, thiosemicarbazone and Ag-ionophore-II ligands were tested to bind Cu-64 in a polymer chain. Labeling yields with no-carrier-added Cu-64 varied from 95 to 99% in 30min. at laboratory temperature. Vectors were stable in vitro for 24h in human serum and might be prospective for targeted Cu-64 radio or combined radiochemotherapy.