脑缺血后内纹状体DA与其代谢产物的变化及电针的干预作用
Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai(2010)
Abstract
目的:观察大鼠脑缺血后纹状体内多巴胺(DA)与其代谢产物的变化以及电针风池穴对其的影响。方法:将18只SD雄性大鼠随机分为正常组、模型组、电针组(造模后电针风池穴治疗)。采用大鼠大脑中动脉阻塞(MCAO)模型。运用微透析采样,高效液相-电化学(HPLC-ED)检测,观察脑缺血后3d内纹状体内DA与其代谢产物的动态变化及电针对其的影响。结果:脑缺血再灌注后DA和高香草酸(HVA)含量下降,3,4-二羟基苯乙酸(DOPAC)含量略有升高;电针干预后第3天DA及其代谢产物含量接近正常组。结论:电针风池穴能调节脑缺血后DA的代谢紊乱。
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Key words
Dopamine,electroacupuncture,Cerebral ischemia-reperfusion,Fengchi(GB 20)
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