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5-(Pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists

Matthew D. Surman,Emily E. Freeman,James F. Grabowski,Mark Hadden,Alan J. Henderson,Guowei Jiang,Xiaowu (May) Jiang,Michele Luche,Yuri Khmelnitsky,Steven Vickers,Jean Viggers,Sharon Cheetham,Peter R. Guzzo

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 26|Views39
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Abstract
The synthesis and SAR of 5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as potent MCH-1 antagonists are described.
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Key words
Melanin concentrating hormone,MCH-1 antagonists,Obesity,Indazoles
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