Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1992)
摘要
Vinylogous hydroxamic acids were prepared as inhibitors of 5-lipoxygenase. The synthesis and preliminary SAR of these relatively unexplored compounds are described. These compounds are potent 5-lipoxygenase inhibitors which do not inhibit other enzymes of the arachidonic acid cascade.
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关键词
lipoxygenase inhibitor,vinylogous hydroxamic acid,hydroxylamine.
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