Mina, an Il4 repressor, controls T helper type 2 bias
NATURE IMMUNOLOGY（2009）
Abstract
Mouse strains show varying inherent biases to T helper type 2 (T H 2) responses. Bix and colleagues identify Mina, a jumonji C protein, as a negative regulator of the gene encoding interleukin 4 whose expression inversely correlates with T H 2 bias.
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Key words
protein family,transcription factor,signaling,gene recombination,nuclear proteins,gene regulation,immune system,antigen presentation,apoptosis,genetic variation,genetics,immunologist,interleukin 4,nature,transgenic mice,innate immunity,cell differentiation,immunology,haplotypes
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