Compared study of fucoidan from sea cucumber (Holothuria tubulosa) with different molecular weight on ameliorating β cell apoptosis

Yujie Zhu,Yufeng Dai,Yuanyuan Liu,Changhu Xue,Yaoguang Chang,Jingfeng Wang

Journal of Functional Foods（2021）

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Abstract

•Ht-FUC ameliorated β cell apoptosis and Ht-2 are more effective.•Ht-FUC suppressed PERK/CHOP and IRE1α/JNK pathways to inhibit ERS.•Ht-FUC inhibited mitochondrial apoptosis pathway in β cell.•Enriched theoretical basis of glycobiology and improved efficient use of FUC.

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Key words

Ht-FUC,β cell apoptosis,FFA,Structure-activity relationship

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