Synthesis of potent and selective inhibitors against the proliferation of human coronary artery smooth muscle cells.
CHEMICAL & PHARMACEUTICAL BULLETIN(2003)
摘要
A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2h was much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of SMCs and the cell selectivity.
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关键词
diarylamide urea,proliferation,coronary artery smooth muscle cell,coronary artery endothelial cell
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