Integrin αvβ6 and Mediators of Extracellular Matrix Deposition Are Up-Regulated in Experimental Biliary Atresia

Conclusions Our data suggest experimental BA is associated with increased mRNA expression of ECM degradation inhibitors, TIMP-1, PAI-1, and TIMP-4. MMP-7 and MMP-9 expression is also elevated in this model. Furthermore, increased gene expression of integrin α v β 6 was demonstrated and IHC confirmed protein expression. Integrin α v β 6 or the inhibitors of ECM breakdown may be attractive targets for future treatment strategies.