Zd1839 (Iressa) Inhibits Anticancer-Drug-Induced Activation Of The Egf/Egfr Autocrine Loop And Il-8 Production In Gastric Cancer Cells

kinase activity of PKD2.Wild type PKD2 was mainly localized in the cytoplasm.Upon addition of gastrin, PKD2 was detectable in the perinuclear region as well as in the nucleus.Nuclear translocation of PKD2 required an intact Zinc finger domain, kinase activity as well as the presence of gastrin.In conclusion, PKD2 is a serine threonine kinase which is activated and translocates to the nucleus in response to gastrin in human gastric cancer cells suggesting a potential role of this kinase as a novel mediator of transcriptional regulation by gastrin.