Some effects of prophylactic aspirins and heparins on concurrent arterial and venous thrombosis in the same animal (vol 92, pg 229, 1998)

The antithrombotic effect of unfractionated heparin (UFH), a low-molecular weight heparin (LMWH), oral acetylsalicylic acid (ASA), intravenous lysine-aspirin (L-ASA) and oral soluble aspirin (S-ASB) was measured on platinum wire simultaneously in artery and vein, in groups of 12-20 rats with concurrent untreated controls. Subcutaneous LMWH and intravenous lysine-aspirin reduced mean thrombus weight by 33% and 19%, respectively, in the artery only. Venous thrombosis was reduced 56% by oral ASA and 26% by oral soluble aspirin. Other reductions did not reach statistical significance. While thrombus deposition was induced by both 2 cm (upper site) and 1 cm (lower site) wires, the results obtained on the 2 cm wires in the upper vein and artery were more reliable. (C) 1998 Elsevier Science Ltd.