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Quinazolinones as γ-secretase modulators.

Christian Fischer,Sanjiv Shah,Bethany L Hughes,George N Nikov,Jamie L Crispino,Richard E Middleton,Alexander A Szewczak,Benito Munoz,Mark S Shearman

Bioorganic & Medicinal Chemistry Letters（2011）

Cited 21|Views39
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Abstract
Synthesis, SAR and evaluation of styrenyl quinazolinones as novel gamma secretase modulators are presented in this communication. Starting from literature and in-house leads we evaluated a range of quinazolinones which showed good modulation of γ-secretase activity.
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Key words
Alzheimer,Gamma Secretase,Modulator,APP,Aβ42 lowering
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