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血清t-PSA及f-PSA/t-PSA比值在前列腺癌诊断中的价值

Laboratory Medicine and Clinic(2012)

Cited 23|Views6
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Abstract
目的探讨血清总前列腺特异性抗原(t-PSA)及游离前列腺特异性抗原(f-PSA)/t-PSA比值在前列腺癌(PCa)诊断中的价值。方法对96例PCa与50例前列腺增生(BPH)患者进行血清t-PSA、f-PSA检测并计算f-PSA/t-PSA比值。结果 PCa与BPH两组患者间t-PSA和f-PSA/t-PSA比值差异有统计学意义(P<0.05)。当t-PSA介于4.0~10.0ng/mL,两组患者间t-PSA差异无统计学意义(P>0.05),而f-PSA/t-PSA比值差异有统计学意义(P<0.05),而且f-PSA/t-PSA比值分别为0.10、0.16、0.25时,对PCa诊断的灵敏度分别为39.1%、67.3%、94.5%;特异性分别为92.5%、85.0%、52.4%。结论血清t-PSA及f-PSA/t-PSA比值在PCa诊断中有重要临床价值。
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Key words
prostate specific antigen,benign prostate hyperplasia,prostatic cancer
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