The Stress-Related Protein P8 Protects Beta Cells from Streptozotocin (Stz)-Induced Cell Death in Vitro

Goenter Paeth,Nikolaos Perakakis,Susanne Ehler,Sandra Van Loosen,Marcus Alt,Timm Stahl, Jochen Selifert

Diabetologie und Stoffwechsel（2008）

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Abstract

Aims: Within the exocrine pancreas, p8 expression is induced by pancreatitis and protects exocrine tissue from inflammatory damage via inhibition of NFkB. In previous work, we investigated the role of p8 within the endocrine pancreas and characterised p8 as a glucose-dependent mediator of beta cell proliferation. Here we investigate the hypothesis that p8 protects beta cells from cell damage by the diabetogenic drug STZ.

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Oxidative Stress

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