Synthesis and antitumor evaluation of octahydro-5-hydroxy-1,5-imino-3-benzazocin-4,7,10-triones

1,2,3,4,5,6,7,10-Octahydro-5-hydroxy-1,5-imino-3-benzazocin-4,7,10-trione (3a) was synthesized from the hexahydro-1,5-imino-9-methoxy-3,8,11-trimethyl-4-oxo-3-benzazocine (4a) in six steps and evaluated for its antitumor activity against L1210 in vitro.