胰腺癌患者血浆TFPI-2基因启动子区甲基化状态检测及意义
Shandong Medical Journal（2011）
Abstract
目的观察胰腺癌患者血浆中组织因子途径抑制物-2(TFPI-2)基因启动子区甲基化状态,并探讨其临床意义。方法采用甲基化特异性聚合酶链反应(MSP)检测62例胰腺癌患者(观察组)及30例胆胰非肿瘤疾病患者(对照组)血浆中的TFPI-2基因甲基化状态。结果观察组血浆TFPI-2基因甲基化阳性率为66.13%(41/62),明显高于正常对照组的3.33%(1/30),P<0.01。血浆TFPI-2基因甲基化与胰腺癌的临床分期、组织分化程度有关(P均<0.05)。结论胰腺癌患者血浆中TFPI-2基因出现异常甲基化;血浆TFPI-2基因甲基化检测可能有助于胰腺癌的早期诊断。
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Key words
methylation,pancreatic carcinoma,pancreatic cancer,DNA,tissue factor pathway inhibitor-2
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