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乳腺癌中EGFR、p53和C-erbB-2基因蛋白表达及意义

赵荧,贾锋,田亚汀,薄爱华

Jiangsu Medical Journal（2009）

Cited 23|Views14
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Abstract
目的 探讨上皮生长因子受体(EGFR),p53和C-erbB-2基因蛋白在乳腺癌中的表达及意义.方法 收集乳腺癌标本98例,用SP免疫组织化学方法,检测EGFR、p53和C-erbB-2基因蛋白的阳性率.结果 EGFR、p53和C-erbB-2在乳腺癌中的阳性率分别为61.22%、46.93%和54.08%.浸润性癌中EGFR和p53阳性率明显高非浸润件癌(P<0.05),淋巴结转移组明显高于无转移组(P<0.05).结论 EGFR,p53和C-erbB-2过表达是乳腺癌预后不良的重要指标.
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Key words
p53,C-erbB-2,Epidermal growth factor receptor,Breast cancer
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