Triton WR-1339诱发小鼠高脂血症模型的研究

Chinese Pharmacological Bulletin(2011)

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Abstract
<正>由于高脂血症可诱发心脑血管等多种相关疾病,因此人们十分关注对其治疗药物的研发和药效评价方法的建立。表面活性剂Triton WR-1339(tyloxapol)诱发动物高脂血症模型,具有操作简便且药效评价快速等特点而被广泛运用。本实验从基因水平探讨Triton WR-1339诱发高脂血症的机制,旨在为该模型用于降血脂药物筛选和药效评价提供有益的实验依据。
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Key words:Trition WR-1339,lipoprotein(LPL),hyperlipoidemia model,triglyceride(TG),hepatic triglyceride lipase(HTGL),total cholesterol(TC)
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