Kilogram-Scale Synthesis of a Highly Selective α1-Adrenoceptor Antagonist (DL-028A)
ORGANIC PROCESS RESEARCH & DEVELOPMENT(2002)
摘要
This work presents an improved eight-step process, leading to kilogram quantities of high-quality DL-028A, an antihypertensive agent. The improvements include reducing the levels of toxic reagents and the removal of dangerous processes and waste gas treatment. Moreover, specification and impurity profiles were determined.
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关键词
synthesis,kilogram-scale
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