盐酸非索非那定杂质的LC-MS检测及结构鉴定
Chinese Journal of Pharmaceuticals(2009)
Abstract
分别用HPLC和LC-MS法分析抗过敏药物盐酸非索非那定两年长期留存样品的杂质变化情况。结果发现3个杂质,主要杂质为α,α-二甲基-4-[4-[4-(羟基二苯甲基)-1-哌啶基]-1-氧代丁基]苯乙酸,两年留样后含量增加了1.53%;其余两个杂质为α,α-二甲基-4-[1-羟基-4-[4-(羟基二苯甲基)-1-哌啶基]丁基]苯乙酸甲酯和α,α-二甲基-4-[1-羟基-4-[4-(羟基二苯甲基)-1-哌啶基]丁基]苯乙酸丁酯,含量基本不变。
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Key words
LC-MS,fexofenadine,determination,impurity
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