RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.

Bharat Lagu,Barbara Pio,Rimma Lebedev,Maria Yang,Patricia D Pelton

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

A number of RXR agonists were synthesized and screened in functional assays. The synthesis and the structure–activity relationship (SAR) within the series of compounds will be presented. Some in vivo data in rodent models for dyslipidemia and diabetes will also be presented.

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关键词

RXR,LXR,Dyslipidemia,ABCA-1,HDL,LDL,Triglycerides,Diabetes

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