血浆(1-3)-β-D-葡聚糖及内毒素检测在重症监护病人早期感染诊断中的应用
Chinese Journal of Health Laboratory Technology(2011)
Abstract
目的:探讨血浆(1-3)-β-D-葡聚糖及内毒素检测在重症监护病人感染早期诊断中的临床意义。方法:根据体液的真菌培养及血培养结果将患者分为2组,比较2组中血浆(1-3)-β-D-葡聚糖及内毒素定量水平差异。结果:真菌培养阳性患者血浆中的(1-3)-β-D-葡聚糖定量水平(65.20±24.55)pg/ml明显高于真菌培养阴性组(23.15±11.07)pg/ml,且(1-3)-β-D-葡聚糖检测法阳性率为58.93%,高于真菌培养法的48.21%,具有统计学差异(P<0.05);同时血培养阳性患者血浆中的内毒素定量水平(88.50±26.85)pg/ml明显高于血培养阴性组(14.50±2.35)pg/ml,且内毒素检测法阳性率为57.14%,高于血培养法的35.71%,具有统计学差异(P<0.05)。结论:血浆(1-3)-β-D-葡聚糖及内毒素定量测定具有快速、敏感的特点,对真菌及革兰阴性菌感染的早期诊断具有一定的临床应用价值。
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Key words
Endotoxin,(1-3)-β-D-glucan,Bacterial infection,Fungal infection
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