In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.

Liming Shao,Michael Hewitt,Thomas P Jerussi,Frank Wu,Scott Malcolm,Paul Grover,Kevin Fang,Patrick Koch,Chris Senanayake,Nandkumar Bhongle,Seth Ribe,Roger Bakale,Mark Currie

Bioorganic & Medicinal Chemistry Letters（2008）

引用 13|浏览16

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摘要

Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.

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关键词

Tramadol,Metabolic stability,Opioids

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