Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: Oxadiazolyl ketones

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

Compound 18h showed excellent inhibitory activity against DPPIV, good selectivity over DPPII and DPPVIII, and showed good PK, PD profile.

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关键词

Oxadiazolyl ketones,DPPIV inhibitors

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