光动力学治疗卵巢癌的体外实验研究
Progress in Obstetrics and Gynecology(2009)
Abstract
目的:探讨血卟啉单甲醚(HMME)光动力治疗卵巢癌的体外治疗效果。方法:不同浓度(0~20μg/ml)HMME联合不同能量激光(0~6J/cm2)处理大鼠上皮性卵巢癌细胞株NuTu-19细胞后,MTT比色法检测细胞存活率;Annexin V/PI双染色,流式细胞仪分析细胞死亡方式。结果:HMME无暗毒性,随着药物浓度与激光剂量的增加,细胞存活率逐渐下降,大剂量可取得完全杀伤的效果,细胞死亡方式以坏死为主。结论:HMME对卵巢癌细胞具有明确的体外光动力学杀伤效应。
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Key words
Rats,Disease model,Photosensitizers,Intraperitoneal photodynamic therapy,Cell line,Ovarian neoplasms,inbred F344,animal
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