The Expression of β-amyloid Precursor Protein in Brain Tissue of Pharmacoresistant Epilepsy Patients by Immunofluorescence Examination

Objective:β-Amyloid precursor protein(β-APP) is known as the key role played in the pathogenesis of Alzheimer's disease(AD).It is now becoming likely that β-APP expression may be associated with refractory epilepsy although the mechanism may not be clear.This study investigated the expression of β-APP protein level in epileptic temporal lobe and hippocampal tissue compared with human control.Methods:We used immunofluorescence to examine the expression of β-A PP protein levels in the temporal lobes and hippocampus of patients with chronic pharmacoresistant epilepsy.Results:Fluorescence intensity of β-APP protein was shown to be increased significantly in the temporal cortex and hippocampus of the epilepsy group of patients.Conclusions:Over expression of β-APP may contribute to the pathogenetic mechanisms of refractory epilepsy.