Synthesis and in vivo evaluation of (S)-6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one, a potential PET tracer for growth hormone secretagogue receptor (GHSR).

Rachel Potter,Andrew G Horti,Hayden T Ravert,Daniel P Holt,Paige Finley,Ursula Scheffel,Robert F Dannals,Richard L Wahl

Bioorganic & Medicinal Chemistry（2011）

Cited 21|Views9

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Abstract

We report the synthesis, in vitro, and in vivo evaluation of 6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one ([11C]) as a potential PET radiotracer for imaging of the Ghrelin Secretagogue Receptor (GHSR).

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Key words

PET,Ghrelin,11C,Growth hormone secretagogue receptor,GHSR

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