Changes of serum high sensitive C-reactive protein in patients with acute cerebral infarction

Methods 2 mL venous blood was selected from hospitalized patients in the next morning to separate serum. Quantitative measurement of hs-CRP was dealt with Latex Enhnced Turbidimetric Immunoassay (LETIA). Fasting venous blood was colleted from hospitalized patients in the next morning to measure numeration of white blood cells, fibrinogen, blood glucose, total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and homocysteine. Measurement data were compared with t test or analysis of variance. Main outcome measures Comparisons of serum biochemical indexes among patients with various levels of hs-CRP; comparisons of risk factors among patients with various levels of hs-CRP; comparisons of levels of hs-CRP among patients with various degrees of clinical neurologic impairment. Results A total of 102 patients were involved in the final analysis. Plasma fibrinogen and numeration of leucocytes were more in the increasing group than those in the normal group ( t =4.39, 3.54, P < 0.01); while, there were no significant differences of blood glucose, TC, TG, HDL-C, LDL-C and homocysteine between the two groups ( P > 0.05). Percentage of patients with hypertension and diabetes mellitus (DM) was higher in the increasing group than the normal group (χ 2 =3.98, 4.23, P < 0.05); while, percentage of patients with smoking in the increasing group was not significantly different from that of patients in the normal group ( P > 0.05). Level of hs-CRP of patients with severe neurologic impairment was higher than that of patients with moderate neurologic impairment ( t =2.273, P < 0.05); that of patients with moderate neurologic impairment was higher than that of patients with mild neurologic impairment ( t =2.586, P < 0.05); that of patients with severe neurologic impairment was obviously higher than that of patients with mild neurologic impairment ( t = 4.913, P < 0.01). Conclusion With the increase of hs-CRP, plasma fibrinogen and numeration of leucocytes of patients with acute cerebral infarction is increased, especially, they are increased remarkably among patients who have history of diabetes mellitus and hypertension. Increase of level of hs-CRP can be regarded as one of marks to evaluate severity of acute stroke. 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