Changes of serum high sensitive C-reactive protein in patients with acute cerebral infarction
Neural Regeneration Research(2007)
Abstract
Methods 2 mL venous blood was selected from hospitalized patients in the next morning to separate serum. Quantitative measurement of hs-CRP was dealt with Latex Enhnced Turbidimetric Immunoassay (LETIA). Fasting venous blood was colleted from hospitalized patients in the next morning to measure numeration of white blood cells, fibrinogen, blood glucose, total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and homocysteine. Measurement data were compared with t test or analysis of variance. Main outcome measures Comparisons of serum biochemical indexes among patients with various levels of hs-CRP; comparisons of risk factors among patients with various levels of hs-CRP; comparisons of levels of hs-CRP among patients with various degrees of clinical neurologic impairment. Results A total of 102 patients were involved in the final analysis. Plasma fibrinogen and numeration of leucocytes were more in the increasing group than those in the normal group ( t =4.39, 3.54, P < 0.01); while, there were no significant differences of blood glucose, TC, TG, HDL-C, LDL-C and homocysteine between the two groups ( P > 0.05). Percentage of patients with hypertension and diabetes mellitus (DM) was higher in the increasing group than the normal group (χ 2 =3.98, 4.23, P < 0.05); while, percentage of patients with smoking in the increasing group was not significantly different from that of patients in the normal group ( P > 0.05). Level of hs-CRP of patients with severe neurologic impairment was higher than that of patients with moderate neurologic impairment ( t =2.273, P < 0.05); that of patients with moderate neurologic impairment was higher than that of patients with mild neurologic impairment ( t =2.586, P < 0.05); that of patients with severe neurologic impairment was obviously higher than that of patients with mild neurologic impairment ( t = 4.913, P < 0.01). Conclusion With the increase of hs-CRP, plasma fibrinogen and numeration of leucocytes of patients with acute cerebral infarction is increased, especially, they are increased remarkably among patients who have history of diabetes mellitus and hypertension. Increase of level of hs-CRP can be regarded as one of marks to evaluate severity of acute stroke. Key words C-reactive protein cerebral infarction risk factors References 1 IM Van Der Meer MP De Maat AE Hak C-reactive protein predicts progressive of atherosclerosis measured at various sites in the arterial tree: the rotterdam study Stroke 33 12 2002 2750 2755 2 L Jialal S Devaraj Inflammation and atherosclerosis: the vaule of the high-sensitivity C-reactive protein assay as a risk marker Am J Clin Pathol 116 Sup 2001 108 115 3 XD Wang Diagnostic gist of various cerebrovascular diseases Zhonghua Shenjingke Zazhi 29 6 1996 379 380 4 QT Chen Scoring standard of neurologic deficit scale for stroke patients Zhonghua Shenjingke Zazhi 29 6 1996 381 382 5 JJ Li GS Li Progess on ruptures of athrosclerotic plague Zhonghua Laonian Xinnao Xueguanbing Zazhi 2 2001 273 278 6 R Kazmierski E Podsiadly S Tylewska-Wierzbanowska Association between carotid atherosclerosis, inflammatory markers and Chlamydia pneumoniae infection Neurol Neurochir Pol 39 4 2005 277 286 7 J Danesh P Whincup M Walker Low grade inflammation and coronary heart disease:prospective study and updated meta-analyses BMJ 321 2000 199 204 8 M Banach L Markuszewski J Zaslonka The role of inflammation in the pathogenesis of atherosclerosis Przegl Epidemiol 58 2004 663 670 9 JT Willerson PM Ridker Inflammation as a cardiovascular risk factor Circulation 109 21 Suppl 1 2004 2 10 10 WK Lagrand CA Visser WT Hermens C-reactive protein as a cardiovascular risk factor more than an epiphenomenon? Circulation 100 1 1999 96 102 11 RP Tracy Inflammation in cardiovascular disease: cart, horse, or both? Circulation 97 20 1998 138 12 HJ Audebert TS Pellkofer ML Wimmer Progression in lacunar stroke is related to elevated acute phase parameters Eur Neurol 51 3 2004 125 131 13 I Iyigun Y Bakirci Plasma concentrations of C-reactive protein and fibrinogen in ischaemic stroke J Int Med Res 30 9 2002 591 596 14 ES Kang HJ Kim YM Kim Serum high sensitivity C -reactive protein is associated with carotid intima-media thickness in type 2 diabetes Diabetes Res Clin Pract 66 Suppl 1 2004 115 120 15 ES Leinonen A Hiukka E Hurt-Camejo Low-grade inflammation, endothelial activation and carotid intima-media thickness in type 2 diabetes J Intern Med 256 2 2004 119 127 16 IM Van Der Meer MP De Maat AE Hak C-reactive protein predicts progression of atherosclerosis measured at various sites in the arterial tree: the Rotterdam Study Stroke 33 12 2002 2750 2755 17 JD Curb RD Abbott BL Rodriguez C-reactive protein and the future risk of thromboembolic stroke in healthy men Circulation 107 15 2003 2016 2020 18 Burke AP, Tracy RP, Kolodgie F, et al. Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies. Circulation 105(17):2019-23. 19 SS Bassuk N Rifai PM Ridker High-sensitivity C-reactive protein: clinical importance Curr Prob Cardiol 29 8 2004 439 493 20 JJ Li CH Fang C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases Med Hypotheses 62 2004 499 506 21 RP Tracy BM Psaty E Macy Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects Arterioscler Thromb Vasc Biol 17 1997 2167 2176 22 K Wallenfeldt J Hulthe L Bokemark Carotid and femoral atherosclerosis. cardiovascular risk factors and C-reactive protein in relation to smokeless tobacco use or smoking in 58-year-old men J Intern Med 250 2001 492 501 23 S Makita M Nakamura K Hiramori The association of C-reactive protein levels with carotid intima-media complex thickness and plaque formation in the general population Stroke 36 10 2005 2138 2142 24 L Gao XD Li JY Nan Changes of the serum levels of hs-CRP between transient ischemic attack and cerebral infarction Zhongguo Jijiu Yixue 23 7 2003 466 469 25 M Di Napeli F Papa V Bocola C-reactive protein in ischemic stroke:an independent prognostic factor Stroke 32 2001 917 924 26 H Peng ZH Guo Relation of C-reactive protein with prognosis and combined multiple organ disfunction syndrome after acute cerebral infaction Zuzhong yu Shenjing Jibing 11 1 2004 10 27 H Bartosik-Psujek E Belnjak Z Stelmnsiak Markers of inflammation in cerebral ischemia Neurol Sci 24 2003 279 280 28 KW Muri CJ Weri W Alwann C-reactive protein and outcome after ischemic stroke Stroke 30 1999 981 985 29 Y Guo X Jiang C-reactive protein as an important prognosric marker for ischemic stroke Zhonghua Yufang Yixue Zazhi 37 3 2003 102 104 30 U Dimagl C Ladecola MA Moskowitz Pathobiology of ischemic stroke: an integrated view Trends Neurosci 22 9 1999 391 397
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Key words
C-reactive protein,cerebral infarction,risk factors
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