胰岛素样生长因子1及其结合蛋白3对胃癌诊断的意义
Laboratory Medicine(2013)
Abstract
目的 评估血清胰岛素样生长因子-1(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)对胃癌及胃癌前病变的临床诊断价值.方法 采用化学发光法、酶联免疫吸附试验(ELISA)和电化学发光法对90例胃癌患者、40例胃良性疾病患者和50名健康体检者血清IGF-1、IGFBP-3、癌胚抗原(CEA)和糖类抗原199(CA199)水平进行检测.结果 胃癌组血清IGF-1水平明显高于胃良性疾病组和健康对照组(P <0.05、P<0.001),血清IGFBP-3水平明显低于胃良性疾病组和健康对照组(P <0.001);胃癌早期(Ⅰ~Ⅱ期)组血清IGF-1水平虽明显低于胃癌晚期(Ⅲ~Ⅳ期)组,但高于健康对照组;IGFBP-3水平虽高于胃癌晚期组,但也低于健康对照组.血清IGF-1与IGFBP-3呈明显负相关,直线相关方程为Y=-0.33X+ 116.65(r=-0.566,P<0.01);血清IGF-1、IGFBP-3与CEA、CA199均无相关性.以健康对照组为对照绘制受试者工作特征(ROC)曲线,IGF-1的ROC曲线下面积(AUC)明显高于CEA和CA199(P<0.01、P<0.05),诊断胃癌的敏感性亦高于CEA和CA199(P<0.05).结论 IGF-1对胃癌的诊断价值优于CEA和CA199,且有助于胃癌分期的评估.
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Key words
Insulin-like growth factor-1,Insulin-like growth factor binding protein-3,Gastric precancerous lesion,Gastric cancer
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