Microwave-assisted synthesis and reactivity of new 5-amino-1H-pyrazole derivatives bearing 2-furoyl moieties

In this study, a novel series of 5-amino-1H-pyrazole derivatives involving 2-furoyl moieties were synthesized in good yields from 2-cyano-3 ethoxyacrylonitrile or ethyl-2-cyano-3-ethoxyacrylate and of various furan-2-carbohydrazide compounds under microwave irradiation. We studied the reactivity of these new compounds toward the orthoesters using the same methodology. All structures were confirmed by analytical and spectral (FT-IR, H-1 NMR, C-13 NMR, and elemental analysis) techniques.