Capillary blood flow and arteriolovenular shunt in various organs in hypotensive states induced by nitroglycerine, nitroprusside, and nicardipine
Journal of Anesthesia(1994)
摘要
The capillary blood flow of 14 organs was measured in dogs using the microsphere (9μm diameter) trapping method under hypotension
induced by administration of either nitroglycerin (NTG), nitroprusside (SNP), or nicardipine (NIC). Simultaneously, blood
flow through the arteriolovenular shunt in the brain, kidney, liver, mesenteric organs, skeletal muscles of the pelvic limb,
and all organs in the body, except the lungs, were measured by collecting venous blood drained from the organs at 4.8 ml·min−1 for 2 min. Capillary blood flow remained unchanged in most organs under hypotension with either NTG or SNP, but in increased
in most organs, together with an increase in cardiac output, under hypotension with NIC. Arteriolovenular shunt tended to
increase in four organs, with the exception of the liver, and increased in the whole body under hypotension with NTG. However,
arteriolovenular shunt remained unchanged under hypotension with SNP. Arteriolovenular shunt increased in the mesenteric organs
under hypotension with NIC, but decreased in the skeletal muscles of the pelvic limb. These results indicated that none of
these hypotensive drugs impairs the nutrient supply to organs; further, NIC protects it much more since it does not increase
the shunt flow through major organs.
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关键词
Arteriolovenular shunt,Capillary blood flow,Hypotensive anesthesia,Nicardipine,Nitroglycerino,Nitroprusside,Organ microcirculation
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