The Evaluation OF 2', 3'-Dideoxy-β-D-Erythro-Hex-2'-Enopyranosyl Nucleosides as Potential Antisense Constructs: Synthesis, Biophysical Properties and Enzymatic Stability of 2'-Deoxyadenosine-(3'-6')-[1-(2', 3'-Dideoxy-β-D-Erythro-Hex-2'-Enopyranosyl)thymine] Phosphate

1-(2',3'-dideoxy-beta-D-erythro-hex-2'-enopryanosyl)thymine was used as a nucleoside substitute in the synthesis of the dimer ApT*. CD studies on the dimer show that it adopts stacked, B-form mini-helices in solution. The title compound, relative to natural ApT, possesses an increased resistance to degradation by nucleases.