MMP-13 selective alpha-sulfone hydroxamates: Identification of selective P1′ amides
Bioorganic & Medicinal Chemistry Letters（2011）
Abstract
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1′ substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
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Key words
MMP,Matrix metalloproteinases,MMP-13,Arthritis inflammation,Hydroxamic acids
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