T Cells Bet On Sugars To Help

Leukocytes emigrate into inflamed tissues by binding to selectins on endothelial cells; while different leukocyte subsets traffic to different tissue sites, the mechanisms regulating selective expression of selectin ligands on specific cell subsets are not known. Underhill and colleagues demonstrate that the signals that drive Th1 cell differentiation also drive expression of the glycosyltransferase enzymes that create selectin ligands on these cells.