黄芩对硫酸镉及丝裂霉素C诱发小鼠遗传损伤的抑制作用

Chinese Journal of Pharmacovigilance(2010)

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Abstract
目的探讨黄芩对硫酸镉及丝裂霉素C(Mitomycin C,MMC)诱发小鼠遗传损伤的抑制作用。方法采用活体小鼠骨髓嗜多染红细胞(PCE)微核试验(Micronucleus test,MNT),计算出含微核的嗜多染红细胞的千分率,进行统计学分析。结果黄芩可使硫酸镉及丝裂霉素C诱发的小鼠骨髓细胞微核(MN)率明显降低,差异具有显著性(P<0.01)。CdS04同时加黄芩各剂量组之间微核率差异无显著性(P>0.05)。结论本实验剂量与条件下黄芩对遗传损伤具有保护作用。
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Key words
micronucleus test,antimutation,Radix Seutellariae
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