[Immunological activity of Streptomyces polysaccharide in normal and immunosuppressed mice].

OBJECTIVE:To investigate the immunological activity of Streptomyces polysaccharide (SMP) on normal and immunosuppressed mice. METHODS:The effect of SMP on the proliferating activity of normal mouse splenocytes was tested in the mixed lymphocyte culture, and the changes of peripheral blood T lymphocytes were evaluated with acid a-naphthyl acetate esterase (ANAE) method. The ratio of Lyt2+ and L3T4+ T cell subsets was measured by flow cytometry. RESULTS:SMP stimulated obvious proliferation of mixed lymphocytes, showed protective effects on T lymphocyte and increased the ratio of Lyt2+ and L3T4+ cell subsets to nearly normal level in immunosuppressed mice. CONCLUSIONS:SMP can regulate the immune function in mice.