ERK1/2在胶质瘤中的表达及意义
Jiangsu Medical Journal(2011)
Abstract
目的探讨细胞外信号调节激酶1/2(ERK1/2)在人脑胶质瘤中的表达及其与胶质瘤的发生发展的关系。方法收集具有明确病理分级的胶质瘤标本48例,WHOⅠ~Ⅱ级15例,Ⅲ级21例,Ⅳ级12例;另取8例正常脑组织作正常对照。用免疫组织化学染色检测ERK1/2和磷酸化ERK1/2(p-ERK1/2)表达水平。结果在胶质瘤组织中,ERK1/2和p-ERK1/2表达均增高,且与胶质瘤恶性程度呈正相关;在Ⅲ、Ⅳ级胶质瘤中,ERK1/2和p-ERK1/2表达水平显著强于Ⅰ、Ⅱ级胶质瘤。结论 ERK1/2在胶质瘤组织中表达水平与胶质瘤的恶性程度有关。
MoreTranslated text
Key words
Glioma,Extracellular signal-regulated protein kinase 1/2
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined