B-cell lymphoproliferation in chronic inflammatory rheumatic diseases

Patients with chronic inflammatory rheumatic diseases, such as primary Sjögren's syndrome, systemic lupus erhythematosus and rheumatoid arthritis, are at higher risk of developing B-cell non-Hodgkin lymphomas compared with the general population. In their Review, Dr Hansen, Dr Lipsky and Dr Dörner discuss the risk of lymphoma, the common and disease-specific mechanisms of B-cell lymphoma development, and the clinical consequences in patients with inflammatory rheumatic diseases.