Incorporation of fluoroprolines to proctolin: Study on the effect of a fluorine atom toward peptidic conformation

Takamasa Kitamoto,Taeko Ozawa,Megumi Abe,Shunsuke Marubayashi,Takashi Yamazaki

Journal of Fluorine Chemistry（2008）

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摘要

The biologically active pentapeptide, proctolin 1, and its monofluorinated derivatives 2 and 3 at the 4 position of proline were synthesized, and their conformations were analyzed on the basis of their NOESY spectra.

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关键词

Fluorinated amino acid,Peptidic conformations,NOESY spectra

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