Approaches to the stereoselective total synthesis of biologically active natural products

PURE AND APPLIED CHEMISTRY(2005)

Cited 6|Views12
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Abstract
Total syntheses of epothilone B and pamamycin 607, which feature reactions between functionalized allylstannanes and aldehydes to introduce a (Z)-trisubstituted double-bond and remote stereocenters stereoselectively, are discussed. Recent work concerned with carrying out this chemistry without the use of allylstannanes as starting materials and progress toward a total synthesis of bryostatins are also presented.
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Key words
biological activity,total synthesis,stereoselectivity
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