Palladium-Catalyzed Preparation Of Weinreb Amides From Boronic Acids And N-Methyl-N-Methoxycarbamoyl Chloride

A simple protocol for the synthesis of Weinreb benzamides and alpha,beta-unsaturated Weinreb amides through a palladium-catalyzed cross-coupling reaction between organoboronic acids and N-methoxy-N-methylcarbamoyl chloride has been developed. The method is also applicable to the use of potassium organotrifluoroborates.